Sunday, March 18, 2012

Fwd: HSI e-Alert - on pain reliever, ageing,



---------- Forwarded message ----------
From: HSI - Jenny Thompson <HSIresearch@newmarkethealth.com>
Date: Sat, Mar 10, 2012 at 7:48 PM
Subject: HSI e-Alert - Pretty in pink



HSI eAlert

You have received this e-mail because our records indicate that you signed up for a free subscription to the HSI eAlert eLetter.


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Dear Reader,

Imagine if we lived in a world where you could get a promotion at work just by changing the color of your shirt. I know, it sounds completely absurd. But for patent drugs, scenarios like these are also surprisingly common.

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A new beginning
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First some history. As you know, the poor drug companies spend many years and many millions (or billions) of dollars creating a new drug. Then as soon as they get a patent and it hits the market all these upstart generic drug companies come along, and like circling sharks they wait for the patent to expire. As soon as it does, the generics hit market and undercut the price until they start selling more of the product than the former patent holder does. At that point what do the drug giants have to show for all their efforts? Just a few billion dollars in profits and a drug they can no longer call their very own.

But before you start to feel too sorry for them...

There's a loophole they can put to use that extends the life of a drug's patent for two and a half years.

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Playing dress up
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The loophole is simple and effective: claiming that their drug has a new use or a newly added chemical property, the drug company applies for a patent extension. Now that may sound reasonable, but consider this: the patent can even be extended if the only change is a new packaging of the drug.

Of course, patents can be extended only if the FDA approves the reformulated drug. But this appears to be a mere rubber-stamping formality: Between 1989 and 2000, a full 2/3 of all the prescription drugs approved by the FDA were nothing more than modified versions of existing drugs. And some of them weren't even modified--they were identical to drugs already on the market. Only 15 percent of the drugs approved during that period could be considered genuinely "new."

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Naming names!
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Among the popular reformulated drugs currently on the market there are some brand names I'm sure you'll recognize. The allergy drug Claritin, for instance, was recently reformulated to become Clarinex. Prilosec, an ulcer medication, became Nexium.

And--this is my favorite--Sarafem, prescribed for relief of premenstrual irritability, is a pink and lavender capsule that is otherwise identical to one of the true celebrities of prescription drugs: Prozac. Prozac! So they made the pill prettier and got a new slogan, forcing users to pay patent prices for two and a half more years. Plus, I wonder how these irritable women would react if they had any idea they were actually being given Prozac.

All of this information comes from a new research report released by the National Institute for Health Care Management (NIHCM) Foundation, a non-profit organization that promotes improvements in health care access, management and quality.

The report also found that the so-called "new" drugs with modified formulas were priced much higher than the drugs they replaced. In other words, the drug giants take their star performers, dress them up in their Sunday best, and then jack up the prices-all with the formal blessing of our friends at the FDA.

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Keeping it real
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There's currently a bill pending in Congress (called the Greater Access to Affordable Pharmaceuticals Act) that would close these patent loopholes and give our pocketbooks a little relief. But if history is any judge, don't expect the pharmaceutical companies to come out the losers.

I'll do my best to keep you updated in future editions of the HSI e-Alert on all the sneaky things the pharmaceutical giants are trying to get past you. In the meantime, if you must rely on a prescription drug, ask your doctor about the specific history of that drug. Otherwise you might get Prozac, renamed and dressed up in a colorful, new, and more expensive package.





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Researchers have just revealed new research on what may be heralded as the missing link in beauty science... a single nutrient that has the power to tap into the process inside the body that determines how fast -- and how well -- you age.

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This innovation has the potential to keep you looking fresh and flawless no matter how many times you've celebrated your "29th" birthday.

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...and another thing

If your glucosamine and chondroitin aren't having the impact you'd hoped, it may be that you're focused on the wrong thing. You might not have heard of synovial fluid before now, but it turns out it's one of the most critical factors in joint comfort.

It's a thick, stringy fluid found in the cavities of joints. This fluid, made mostly of hyaluronic acid (HA), reduces friction between the cartilage and other tissues in joints, lubricating and cushioning them during movement.

Of course, like so many (SO many!) other things, synovial fluid breaks down as we age. Without the "gel pack" of synovial fluid protecting them, joints and cartilage are left bare. So they rub against one another, -- and, OUCH, can that hurt.

Think about that stiff feeling you get when you suddenly stand after sitting for a long time -- the synovial fluid has stiffened up. It usually takes just a few moments to get flowing again. But what about when it takes longer?

Glucosamine is great for helping rebuild the cartilage that's rubbing away, but it won't do anything for synovial fluid. For that, you have to replenish the very thing it's made of. HA is present in nearly all the tissues of your body, but it's particularly important to the makeup of your skin as well as to the synovial fluid that cushions your joints (where it's the primary force in keeping joints lubricated).

It may also stimulate collagen production and plays an important role in the tissue-repair process.

And by replacing the diminishing HA in synovial fluid, you could actually help keep "bare joints" comfortable.

But the challenge is that most HA only works when it is injected directly into the site where it was needed. Without getting too technical on you, it has to do with the size of the HA molecules -- because they are so large, when taken orally, they weren't properly absorbed by the body. But new research -- and a brand new approach to isolating HA -- is changing all that. And it's starting to show that HA could do the job even when swallowed in a pill.

And that is very good news for your joints, indeed.

To your good health,

Jenny Thompson



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Sources:


The information in this e-mail is offered as a general guideline, not one-size-fits-all medical advice. Talk to your doctor before making any changes in your personal health care regimen.


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